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The INT²GRATE platform incorporates tumor-derived signature somatic profiles in selected cancers, with key clinical genetics information, to aid interpretation of germline variants and assessment of their clinical utility in cancer susceptibility genes. INT²GRATE facilitates the assembly of the integrated evidence from tumor and germline data to promote sharing data and knowledge in ClinVar and other public archives.

In selected inherited cancer syndromes, INT²GRATE requires:

•         Germline variants in relevant cancer susceptibility genes

•         Personal and familial genetics information

•         Somatic genomic information and relevant tumor signature profiles


Disclaimer

This website is provided to the general public for reference and educational purposes only. The content is not meant to be complete or exhaustive or to be applicable to any specific individual’s medical condition. Mass General Brigham does not independently verify the submitted information. This website is not an attempt to practice medicine or provide medical advice, and it should not be used to make a diagnosis or to replace or overrule a health care provider’s judgment. The content on this website is not intended to be a substitute for professional medical advice, diagnosis or treatment. Always consult with a qualified and licensed physician or other medical care provider, and follow their advice without delay regardless of anything read on this website. If you have questions about the information on this website, please contact a health care professional.


Disclaimer


This website is provided to the general public for reference and educational purposes only. The content is not meant to be complete or exhaustive or to be applicable to any specific individual’s medical condition. Mass General Brigham does not independently verify the submitted information. This website is not an attempt to practice medicine or provide medical advice, and it should not be used to make a diagnosis or to replace or overrule a health care provider’s judgment. The content on this website is not intended to be a substitute for professional medical advice, diagnosis or treatment. Always consult with a qualified and licensed physician or other medical care provider, and follow their advice without delay regardless of anything read on this website. If you have questions about the information on this website, please contact a health care professional.